Terminology Service for NFDI4Health
microglial cell
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http://purl.obolibrary.org/obo/CL_0000129
A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive. [ http://www.ncbi.nlm.nih.gov/pubmed/16177057 http://www.ncbi.nlm.nih.gov/pubmed/19461673 http://www.ncbi.nlm.nih.gov/pubmed/14561199 http://www.ncbi.nlm.nih.gov/pubmed/14612429 http://www.ncbi.nlm.nih.gov/pubmed/12430718 http://www.ncbi.nlm.nih.gov/pubmed/2089275 http://www.ncbi.nlm.nih.gov/pubmed/11517395 http://id.nlm.nih.gov/mesh/D017628 https://www.worldcat.org/search?q=bn%3A0721601464 http://en.wikipedia.org/wiki/Microglia ]
Term info
Label
microglial cell
Synonyms
- brain-resident macrophage
- hortega cells
- microglia
- microgliocyte
Subsets
human_reference_atlas
RO 0002175
http://purl.obolibrary.org/obo/NCBITaxon_9606
comment
Unlike macroglial cells, microglial cells arise from hematopoietic stem cells in the yolk sac during early embryogenesis that populate the central nervous system. They derive from embryonic mesoderm and are not from neuroectoderm where glioblast develops from. Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive.
has broad synonym
brain macrophage
has related synonym
MF.microglia.CNS