Terminology Service for NFDI4Health
macrophage
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http://purl.obolibrary.org/obo/CL_0000235
A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells. [ http://www.ncbi.nlm.nih.gov/pubmed/1919437 http://purl.obolibrary.org/obo/go/references/0000031 http://www.ncbi.nlm.nih.gov/pubmed/16213494 ]
Term info
Label
macrophage
Synonyms
- histiocyte
Subsets
human_reference_atlas
RO 0002175
http://purl.obolibrary.org/obo/NCBITaxon_9606
comment
Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid.