Terminology Service for NFDI4Health

interleukin-6 receptor measurement

Go to external page http://www.ebi.ac.uk/efo/EFO_0004814


Is a quantification of the IL-6 receptor (CD126), activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.

Term info

Label

interleukin-6 receptor measurement

definition citation

http://www.uniprot.org/uniprot/P05231, http://en.wikipedia.org/wiki/Interleukin-6_receptor, http://www.uniprot.org/uniprot/P08887

gwas trait

true

term editor

Helen Parkinson