Terminology Service for NFDI4Health
5-HIAA measurement
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http://www.ebi.ac.uk/efo/EFO_0005132
quantification of 5-hydroxyindoleacetic acid in cerebrospinal fluid or urine. 5-HIAA is a metabolite of serotonin. This measurement is performed during diagnosis of serotonin secreting neuroendocrine tumours. Low levels of 5-HIAA in the cerebrospinal fluid have been associated with aggressive behavior and suicide by violent means, correlating with diminished serotonin levels. Elevated serotonin (hyperserotonemia) is one of the most common biological findings in autism[3] and 5-HIAA may be elevated in patients with autistic spectrum disorders.
Term info
Label
5-HIAA measurement
Synonyms
- 5-Hydroxyindoleacetic acid measurement
definition citation
https://en.wikipedia.org/wiki/5-Hydroxyindoleacetic_acid, www.ncbi.nlm.nih.gov/pubmed/25140149
gwas trait
true
term editor
Dani Welter, Helen Parkinson
Term relations
Subclass of:
- metabolite measurement
- cancer biomarker measurement
- is_about some (
carcinoid tumor and
has_role some biomarker) - is_about some 5-HIAA
- is_about some central nervous system