Terminology Service for NFDI4Health
JSON

MAPK cascade

Go to external page http://purl.obolibrary.org/obo/GO_0000165

An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. [ http://www.ncbi.nlm.nih.gov/pubmed/20811974 http://www.ncbi.nlm.nih.gov/pubmed/9561267 ]

Term info

Label

MAPK cascade

Synonyms
  • MAP kinase cascade
  • MAP kinase kinase kinase cascade
  • MAPK signal transduction
  • MAPKKK cascade
  • mitogen-activated protein kinase cascade
database cross reference
comment

MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier.

has narrow synonym

MAPKKK cascade during sporulation, ERK/MAPK cascade

has obo namespace

biological_process

has related synonym

MAPK signalling, MAPK signaling

id

GO:0000165