Terminology Service for NFDI4Health
release of cytochrome c from mitochondria
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http://purl.obolibrary.org/obo/GO_0001836
The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation. [ https://www.worldcat.org/search?q=bn%3A0721639976 http://www.ncbi.nlm.nih.gov/pubmed/9560217 http://www.ncbi.nlm.nih.gov/pubmed/12925707 ]
Term info
Label
release of cytochrome c from mitochondria
comment
The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that are directly involved in this process. An example is Drp1 (DNM1L, UniProt symbol O00429) in PMID:20850011.
has obo namespace
biological_process
id
GO:0001836