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DNA-binding transcription factor activity

Go to external page http://purl.obolibrary.org/obo/GO_0003700

A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. [ ]

Term info

Label

DNA-binding transcription factor activity

Synonyms
  • DNA binding transcription factor activity
  • gene-specific transcription factor activity
  • sequence-specific DNA binding transcription factor activity
Subsets

goslim_chembl, goslim_generic, goslim_metagenomics, goslim_drosophila, goslim_agr, goslim_mouse, goslim_plant, goslim_yeast, goslim_candida, goslim_aspergillus

comment

Curator guidance: Note that most DNA-binding transcription factors do not have enzymatic activity. The presence of specific domains known to be present in DNA-binding transcription factors (HOX, GATA etc) should be used to help decide whether a protein is a DNA binding transcription factor or a coregulator. If a protein has an enzymatic activity (for example, ubiquitin ligase, histone acetyl transferase) and no known DNA binding domain, consider annotating to GO:0003712 transcription coregulator activity. Special care should be taken with proteins containing Myb/SANT and ARID domains, since only a subset of proteins containing these domains are DNA-binding transcription factors for specific genes. Changed definition see https://github.com/geneontology/go-ontology/issues/15704 Merged term see https://github.com/geneontology/go-ontology/issues/16534

created by

kchris

creation date

2010-10-21T04:37:54Z

has alternative id

GO:0001199, GO:0000130, GO:0001131, GO:0001130, GO:0001151, GO:0001071, GO:0001204

has broad synonym

transcription factor activity, nucleic acid binding transcription factor activity

has narrow synonym

transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific binding, metal ion regulated sequence-specific DNA binding transcription factor activity, metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity, bacterial-type DNA binding transcription factor activity, transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding, bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity, transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding, sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity, bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding, bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity, bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding, transcription factor activity, metal ion regulated sequence-specific DNA binding

has obo namespace

molecular_function

id

GO:0003700