transcription corepressor activity
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators. [ http://www.ncbi.nlm.nih.gov/pubmed/16858867 http://www.ncbi.nlm.nih.gov/pubmed/10213677 ]
Term info
transcription corepressor activity
- transcription co-repressor activity
- transcription corepressor activity
Updated definition, see https://github.com/geneontology/go-ontology/issues/15998; Merged children terms, see https://github.com/geneontology/go-ontology/issues/15665
kchris
2010-11-24T03:14:44Z
GO:0001106
molecular_function
RNA polymerase II transcription corepressor activity, RNA polymerase II transcription co-repressor activity
GO:0003714