Terminology Service for NFDI4Health

transcription corepressor activity

Go to external page http://purl.obolibrary.org/obo/GO_0003714


A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators. [ http://www.ncbi.nlm.nih.gov/pubmed/16858867 http://www.ncbi.nlm.nih.gov/pubmed/10213677 ]

Term info

Label

transcription corepressor activity

Synonyms
  • transcription co-repressor activity
  • transcription corepressor activity
comment

Updated definition, see https://github.com/geneontology/go-ontology/issues/15998; Merged children terms, see https://github.com/geneontology/go-ontology/issues/15665

created by

kchris

creation date

2010-11-24T03:14:44Z

has alternative id

GO:0001106

has obo namespace

molecular_function

has related synonym

RNA polymerase II transcription corepressor activity, RNA polymerase II transcription co-repressor activity

id

GO:0003714