Terminology Service for NFDI4Health

eukaryotic translation initiation factor 3 complex

Go to external page http://purl.obolibrary.org/obo/GO_0005852


A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. [ http://www.ncbi.nlm.nih.gov/pubmed/15904532 ]

Term info

Label

eukaryotic translation initiation factor 3 complex

Synonyms
  • eIF-3
  • eIF3
has obo namespace

cellular_component

id

GO:0005852

Term relations