Terminology Service for NFDI4Health
mitochondrial pyruvate dehydrogenase complex
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http://purl.obolibrary.org/obo/GO_0005967
Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The This Eukaryotic form usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase. [ https://www.worldcat.org/search?q=bn%3A0716720094 https://www.worldcat.org/search?q=bn%3A0471331309 ]
Term info
Label
mitochondrial pyruvate dehydrogenase complex
comment
Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'.
has broad synonym
pyruvate dehydrogenase complex (lipoamide)
has obo namespace
cellular_component
id
GO:0005967