Terminology Service for NFDI4Health

SRP-dependent cotranslational protein targeting to membrane, translocation

Go to external page http://purl.obolibrary.org/obo/GO_0006616


The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen. [ https://www.worldcat.org/search?q=bn%3A0716731363 ]

Term info

Label

SRP-dependent cotranslational protein targeting to membrane, translocation

Synonyms
  • SRP-dependent cotranslational membrane targeting, translocation
  • SRP-dependent cotranslational protein-membrane targeting, translocation
  • translocation during SRP-dependent cotranslational protein targeting to membrane
has broad synonym

ER translocation

has obo namespace

biological_process

id

GO:0006616