A protein complex that is located in the cell membrane, and is involved in the metabolism of peptides, including neuropeptides. The complex has metalloendopeptidase activity that catalyzes the hydrolysis of protein and peptide substrates, preferentially on carboxyl side of hydrophobic residues. [ https://enzyme.expasy.org/EC/3.4.24.18 http://merops.sanger.ac.uk/cgi-bin/famsum?family=M12 ]