Nomenclature note. Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Some authors however use the name floppase to denote any enzyme catalyzing transbilayer lipid motion, in some cases even in the absence of ATP requirements (PMID 20043909).

molecular_function

GO:0017128

• phosphatidylserine exposure on apoptotic cell surface

• regulation of phospholipid scramblase activity

• positive regulation of phospholipid scramblase activity

• negative regulation of phospholipid scramblase activity