Terminology Service for NFDI4Health
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beta-catenin destruction complex

Go to external page http://purl.obolibrary.org/obo/GO_0030877

A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome. [ http://www.ncbi.nlm.nih.gov/pubmed/14600025 ]

Term info

Label

beta-catenin destruction complex

Synonyms
  • APC-Axin-1-beta-catenin complex
  • Axin-APC-beta-catenin-GSK3B complex
  • BDC
  • beta-catenin degradation complex
comment

Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.

has alternative id

GO:0034742, GO:0034747

has narrow synonym

23S APC complex

has obo namespace

cellular_component

id

GO:0030877

Term relations