A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway. [ http://www.ncbi.nlm.nih.gov/pubmed/17121544 http://www.ncbi.nlm.nih.gov/pubmed/10585443 http://www.ncbi.nlm.nih.gov/pubmed/9580671 ]