Terminology Service for NFDI4Health

MKS complex

Go to external page http://purl.obolibrary.org/obo/GO_0036038


A protein complex that is located at the ciliary transition zone and consists of several proteins some of which are membrane bound. Acts as an organiser of transition zone inner structure, specifically the Y-shaped links, in conjunction with the NPHP complex. The MKS complex also acts as part of the selective barrier that prevents diffusion of proteins between the ciliary cytoplasm and cellular cytoplasm as well as between the ciliary membrane and plasma membrane. [ http://www.ncbi.nlm.nih.gov/pubmed/21422230 http://www.ncbi.nlm.nih.gov/pubmed/22179047 http://www.ncbi.nlm.nih.gov/pubmed/21565611 http://www.ncbi.nlm.nih.gov/pubmed/21725307 http://www.ncbi.nlm.nih.gov/pubmed/25869670 http://www.ncbi.nlm.nih.gov/pubmed/26982032 http://www.ncbi.nlm.nih.gov/pubmed/26595381 ]

Term info

Label

MKS complex

Synonyms
  • MKS module
comment

Although there is some evidence, it is still unclear if the MKS and NPHP complexes are constituents parts of the Y-shaped links or are simply responsible for aligning and attaching the Y-shaped links to the membrane and axoneme.

created by

rfoulger

creation date

2011-11-22T11:21:28Z

has broad synonym

TCTN-B9D complex

has narrow synonym

tectonic complex, tectonic-like complex, B9 complex

has obo namespace

cellular_component

id

GO:0036038