Terminology Service for NFDI4Health
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vascular endothelial growth factor signaling pathway

Go to external page http://purl.obolibrary.org/obo/GO_0038084

A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. [ https://proconsortium.org/app/entry/000017284 https://proconsortium.org/app/entry/000003096 https://proconsortium.org/app/entry/000017285 http://www.ncbi.nlm.nih.gov/pubmed/17470632 https://proconsortium.org/app/entry/000007520 ]

Term info

Label

vascular endothelial growth factor signaling pathway

Synonyms
  • VEGF signaling
  • VEGF-activated signaling pathway
  • vascular endothelial growth factor signalling pathway
comment

In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0038084 is for annotation of any pathway in which the ligand VEGF binds and activates any cell surface receptor (VEGFR, PDGFR etc.). For annotation of signaling pathways where a VEGFR binds one of its physiological ligands (VEGF or an alternative growth factor), consider 'vascular endothelial growth factor receptor signaling pathway ; GO:0048010'.

created by

rfoulger

creation date

2012-02-01T02:27:32Z

has obo namespace

biological_process

id

GO:0038084