Terminology Service for NFDI4Health
MHC class I peptide loading complex
Go to external page
http://purl.obolibrary.org/obo/GO_0042824
A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules. [ http://www.ncbi.nlm.nih.gov/pubmed/10631934 ]
Term info
Label
MHC class I peptide loading complex
Synonyms
- peptide-loading complex
Subsets
goslim_pir
comment
Note that although this complex is located in the endoplasmic reticulum, there is some evidence that it may also be found in the Golgi.
has obo namespace
cellular_component
id
GO:0042824
Term relations
Subclass of:
- membrane protein complex
- part of some endoplasmic reticulum
- part of some integral component of endoplasmic reticulum membrane
Related from: