Terminology Service for NFDI4Health
cytosolic pyruvate dehydrogenase complex
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http://purl.obolibrary.org/obo/GO_0045250
Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order. [ https://www.worldcat.org/search?q=bn%3A0716720094 https://www.worldcat.org/search?q=bn%3A0471331309 ]
Term info
Label
cytosolic pyruvate dehydrogenase complex
comment
Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'.
has obo namespace
cellular_component
has related synonym
pyruvate dehydrogenase complex (lipoamide)
id
GO:0045250