Terminology Service for NFDI4Health
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vascular endothelial growth factor receptor signaling pathway

Go to external page http://purl.obolibrary.org/obo/GO_0048010

Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. [ https://proconsortium.org/app/entry/000001971 ]

Term info

Label

vascular endothelial growth factor receptor signaling pathway

Synonyms
  • VEGF receptor signaling pathway
  • VEGF receptor signalling pathway
  • VEGFR signaling pathway
comment

In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. In contrast, the VEGFR refers to PR:000001971. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0048010 is for annotation of any pathway in which a ligand (VEGF or an alternative growth factor) binds and activates a VEGFR (PR:000001971). For annotation of signaling pathways where a VEGF binds to a cell surface receptor (VEGFR, PDGFR etc.), consider 'vascular endothelial growth factor signaling pathway ; GO:0038084'.

has obo namespace

biological_process

id

GO:0048010