Terminology Service for NFDI4Health

canonical Wnt signaling pathway

Go to external page http://purl.obolibrary.org/obo/GO_0060070


The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. [ http://www.ncbi.nlm.nih.gov/pubmed/11532397 http://www.ncbi.nlm.nih.gov/pubmed/19619488 ]

Term info

Label

canonical Wnt signaling pathway

Synonyms
  • Wnt receptor signaling pathway through beta-catenin
  • Wnt receptor signaling pathway via beta-catenin
  • Wnt receptor signalling pathway through beta-catenin
  • canonical Wnt receptor signaling pathway
  • canonical Wnt-activated signaling pathway
has narrow synonym

frizzled-1 receptor signaling pathway

has obo namespace

biological_process

id

GO:0060070