Tapasin-ERp57 complex
Subunit of the MHC class I peptide loading complex (GO:0042824) (=PLC) involved in the assembly of the heavy-chain-beta2-microglobulin dimers of the MHC class I molecules that fold with eight to ten residue peptides in the endoplasmic reticulum. Required for the inhibition of the reduction of the disulfide bonds of the heavy chains and the assembly and stabilization of the PLC, suggesting it may play a structural rather than a catalytic role. [ http://www.ncbi.nlm.nih.gov/pubmed/17603487 ]
Term info
Tapasin-ERp57 complex
dph
2016-08-05T12:12:08Z
cellular_component
GO:0061779