Terminology Service for NFDI4Health
ripoptosome
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http://purl.obolibrary.org/obo/GO_0097342
A protein complex whose core components are the receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (also called RIP1 and RIP3). Formation of the ripoptosome can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more. [ http://www.ncbi.nlm.nih.gov/pubmed/22274400 http://www.ncbi.nlm.nih.gov/pubmed/22265414 ]
Term info
Label
ripoptosome
comment
It has been shown that receptor-mediated necroptotic signaling pathway requires assembly of a ripoptosome protein complex consisting of caspase-8, caspase-10, Fas-associated death domain protein (FADD), casp8 and FADD-like apoptosis regulator (CFLAR) as well as the two receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (PMID:21737330). Optionally, depending on the receptor activated, this complex may contain TLR3 adaptor protein TRIF (PMID:21737330).
created by
paola
creation date
2012-06-18T12:55:34Z
has narrow synonym
Tnfr1-CII, TNFR1 complex II
has obo namespace
cellular_component
has related synonym
necrosome
id
GO:0097342