general transcription initiation factor activity
An activity that contributes to transcription start site selection and transcription initiation. [ ]
Term info
general transcription initiation factor activity
- GTF activity
- basal transcription factor activity
- general transcription factor activity
gocheck_do_not_annotate
General transcription factors assemble with the RNA polymerase at promoter DNA to form the pre-initiation complex (PIC), bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present in all promoters to initiate transcription. The distinction between general transcription factors and DNA-binding transcription factors is that the latter modulate the selection of which genes are expressed under specific conditions, while general transcription factors belong to the constitutive machinery required for transcription to occur.
pg
2018-05-24T07:51:23Z
molecular_function
GO:0140223