Terminology Service for NFDI4Health
floppase activity
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http://purl.obolibrary.org/obo/GO_0140328
Catalysis of the movement of a lipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP. [ http://en.wikipedia.org/wiki/Flippase http://www.ncbi.nlm.nih.gov/pubmed/25284293 http://www.ncbi.nlm.nih.gov/pubmed/20043909 ]
Term info
Label
floppase activity
Synonyms
- floppase activity (cytosolic to exoplasmic leaftlet)
comment
Nomenclature note. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. Some authors however use the names flippases and floppases interchangeably to denote any enzyme catalyzing transbilayer lipid motion, in some cases even in the absence of ATP requirements (PMID 20043909). The direction of the translocation should be taken into account for annotation.
created by
pg
creation date
2019-04-29T12:58:53Z
has obo namespace
molecular_function
id
GO:0140328