Terminology Service for NFDI4Health

platelet-derived growth factor receptor-ligand complex

Go to external page http://purl.obolibrary.org/obo/GO_1990270


A tetrameric protein complex consisting of two platelet-derived growth factor (PDGF) receptor subunits and two PDGF ligand subunits. Binding of the PDGF ligand dimer to the PDGF receptor in the plasma membrane induces receptor dimerisation and activation. PDGFs are involved in a wide variety of signalling processes and are found in all vertebrates. At least two different receptor chains (A and B) and four types of ligand chains (A, B, C, and D) are known forming a wide variety of combinations of receptor-ligand complexes. [ http://www.ncbi.nlm.nih.gov/pubmed/11331882 ]

Term info

Label

platelet-derived growth factor receptor-ligand complex

Synonyms
  • PDGF receptor-ligand complex
database cross reference
comment

An example of this is PDGFA-PGFRA in human (UniProt symbols P04085, P16234) in PMID:7679113 (inferred from direct assay).

creation date

2014-01-14T11:12:22Z

has broad synonym

PDGF complex, receptor-ligand complex

has narrow synonym

PDGF-AB-receptor alpha complex, PDGF-BB-receptor alpha complex, PDGF-CC-receptor beta complex, PDGF-CC-receptor alpha complex, PDGF-DD-receptor alpha-beta complex, PDGF-DD-receptor beta complex, PDGF-AA-receptor alpha complex, PDGF-CC-receptor alpha-beta complex, PDGF-BB-receptor alpha-beta complex, PDGF-BB-receptor beta complex, PDGF-AB-receptor beta complex

has obo namespace

cellular_component

id

GO:1990270