platelet-derived growth factor receptor-ligand complex
A tetrameric protein complex consisting of two platelet-derived growth factor (PDGF) receptor subunits and two PDGF ligand subunits. Binding of the PDGF ligand dimer to the PDGF receptor in the plasma membrane induces receptor dimerisation and activation. PDGFs are involved in a wide variety of signalling processes and are found in all vertebrates. At least two different receptor chains (A and B) and four types of ligand chains (A, B, C, and D) are known forming a wide variety of combinations of receptor-ligand complexes. [ http://www.ncbi.nlm.nih.gov/pubmed/11331882 ]
Term info
platelet-derived growth factor receptor-ligand complex
- PDGF receptor-ligand complex
An example of this is PDGFA-PGFRA in human (UniProt symbols P04085, P16234) in PMID:7679113 (inferred from direct assay).
bhm
2014-01-14T11:12:22Z
PDGF complex, receptor-ligand complex
PDGF-AB-receptor alpha complex, PDGF-BB-receptor alpha complex, PDGF-CC-receptor beta complex, PDGF-CC-receptor alpha complex, PDGF-DD-receptor alpha-beta complex, PDGF-DD-receptor beta complex, PDGF-AA-receptor alpha complex, PDGF-CC-receptor alpha-beta complex, PDGF-BB-receptor alpha-beta complex, PDGF-BB-receptor beta complex, PDGF-AB-receptor beta complex
cellular_component
GO:1990270