A protein complex of the endoplasmic reticulum membrane that consists of IRE1 (Inositol-requiring enzyme-1), TRAF2 (TNF receptor-associated factor 2) and ASK1 (Apoptosis signal-regulating kinase 1, a MAP3K). [ http://www.ncbi.nlm.nih.gov/pubmed/12050113 http://www.ncbi.nlm.nih.gov/pubmed/23000344 ]