NPHP complex
A protein complex that is located at the ciliary transition zone and consists of the NPHP4 and NPHP1 proteins. It acts as an organiser of the transition zone inner structure, specifically the Y-shaped links, in conjunction with the MKS complex. It is involved in ciliary protein trafficking and is required for correct functioning of the WNT and Hippo signaling pathways. [ http://www.ncbi.nlm.nih.gov/pubmed/21422230 http://www.ncbi.nlm.nih.gov/pubmed/21555462 http://www.ncbi.nlm.nih.gov/pubmed/18337471 http://www.ncbi.nlm.nih.gov/pubmed/21498478 http://www.ncbi.nlm.nih.gov/pubmed/25150219 ]
Term info
NPHP complex
- NPHP module
Although there is some evidence, it's still unclear if the MKS and NPHP complexes are constituent parts of the ciliary Y-shaped links or are simply responsible for aligning and attaching the Y-shaped links to the cilium membrane and axoneme.
pr
2016-06-06T10:59:45Z
cellular_component
GO:1990957