Terminology Service for NFDI4Health
hematopoietic stem cell
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http://purl.obolibrary.org/obo/CL_0000037
A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119. [ http://www.ncbi.nlm.nih.gov/pubmed/19022770 http://en.wikipedia.org/wiki/Hematopoietic_stem_cell ]
Term info
Label
hematopoietic stem cell
Synonyms
- HSC
- blood forming stem cell
- hemopoietic stem cell
comment
Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative.
has obo namespace
cell
has related synonym
colony forming unit hematopoietic
Term relations
Equivalent to:
- hematopoietic cell and capable_of some hematopoietic progenitor cell differentiation and capable_of some somatic stem cell division and lacks_plasma_membrane_part some CD19 molecule and lacks_plasma_membrane_part some CD4 molecule and lacks_plasma_membrane_part some integrin alpha-M and lacks_plasma_membrane_part some CD3 epsilon and lacks_plasma_membrane_part some neural cell adhesion molecule 1 and lacks_plasma_membrane_part some CD2 molecule and lacks_plasma_membrane_part some T-cell surface glycoprotein CD8 alpha chain and lacks_plasma_membrane_part some membrane-spanning 4-domains subfamily A member 1 and lacks_plasma_membrane_part some T-cell surface glycoprotein CD5 and lacks_plasma_membrane_part some CD14 molecule and lacks_plasma_membrane_part some lymphocyte antigen 6G and lacks_plasma_membrane_part some lymphocyte antigen 76 (mouse)
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Related from: