Terminology Service for NFDI4Health

apoptotic process

Go to external page http://purl.obolibrary.org/obo/GO_0006915


A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [ http://www.ncbi.nlm.nih.gov/pubmed/18846107 https://www.worldcat.org/search?q=bn%3A0198506732 http://www.ncbi.nlm.nih.gov/pubmed/21494263 ]

Term info

Label

apoptotic process

Synonyms
  • apoptotic cell death
  • apoptotic programmed cell death
  • programmed cell death by apoptosis
database cross reference
Subsets

goslim_pombe

has alternative id

GO:0006917, GO:0008632

has broad synonym

cellular suicide, cell suicide

has narrow synonym

apoptosis signaling, apoptosis, type I programmed cell death, apoptotic program, activation of apoptosis

has obo namespace

biological_process

has related synonym

caspase-dependent programmed cell death, commitment to apoptosis, signaling (initiator) caspase activity, induction of apoptosis by p53, induction of apoptosis, apoptosis activator activity

id

GO:0006915