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glyoxalase III activity

Go to external page http://purl.obolibrary.org/obo/GO_0019172

Catalysis of the reaction: methylglyoxal + H2O = D-lactate. [ http://www.ncbi.nlm.nih.gov/pubmed/7848303 http://www.brenda-enzymes.org/php/result_flat.php4?ecno=4.2.1.130 http://www.rhea-db.org/reaction.xhtml?id=27754 http://biocyc.org/META/NEW-IMAGE?type=NIL&object=GLYOXIII-RXN https://enzyme.expasy.org/EC/4.2.1.130 http://www.ncbi.nlm.nih.gov/pubmed/21696459 ]

Term info

Label

glyoxalase III activity

Synonyms
  • (R)-lactate hydro-lyase
  • D-lactate dehydratase
database cross reference
comment

Note that this term was reinstated from obsolete. Also note that this enzymatic activity converts methylglyoxal to D-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalyzed by EC 4.4.1.5 (lactoylglutathione lyase) and EC 3.1.2.6 (hydroxyacylglutathione hydrolase).

has obo namespace

molecular_function

has related synonym

glutathione-independent glyoxalase activity

id

GO:0019172