Terminology Service for NFDI4Health

necrotic cell death

Go to external page http://purl.obolibrary.org/obo/GO_0070265


A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues. [ http://www.ncbi.nlm.nih.gov/pubmed/18846107 http://www.ncbi.nlm.nih.gov/pubmed/20823910 ]

Term info

Label

necrotic cell death

Synonyms
  • cellular necrosis
comment

Note that the word necrosis has been widely used in earlier literature to describe forms of cell death which are now known by more precise terms, such as apoptosis. Necrosis can occur in a regulated fashion, involving a precise sequence of signals; in this case, consider annotating to GO:0097300 'programmed necrotic cell death' or to its more specific child GO:0070266 'necroptotic process'.

has obo namespace

biological_process

id

GO:0070265