Terminology Service for NFDI4Health
Eye of the tiger anomaly of globus pallidus
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http://purl.obolibrary.org/obo/HP_0002454
The presence, on T2-weighted magnetic resonance imaging, of markedly low signal intensity if the globus pallidus that surrounds a central region of high signal intensity in the anteromedial globus pallidus, producing an eye-of-the-tiger appearance. [ http://www.ncbi.nlm.nih.gov/pubmed/11110959 http://www.ncbi.nlm.nih.gov/pubmed/19881070 ]
Term info
Label
Eye of the tiger anomaly of globus pallidus
comment
This sign is observed upon magnetic resonance tomography (MRI). It can be seen in several diseases including Hallervorden-Spatz syndrome, where the pathophysiology has been hypothesized to be related to iron deposition in the globus pallidus (associated with low signal intensity on T2-weighted images) accompanied by other pathological processes such as gliosis and water accumulation that are responsible for the high signal intensity at the central globus pallidus.
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human_phenotype
id
HP:0002454