Terminology Service for NFDI4Health
Impaired sensitivity to thyroid hormone
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http://purl.obolibrary.org/obo/HP_0002930
Reduced sensitivity of end organs to thyroid hormone characterized by elevated serum levels of free thyroid hormone with nonsuppressed thyroid stimulating hormone. [ http://www.ncbi.nlm.nih.gov/pubmed/24847459 ]
Term info
Label
Impaired sensitivity to thyroid hormone
Synonyms
- Elevated serum levels of free thyroid hormone with nonsuppressed TSH
- End-organ unresponsiveness to thyroid hormone
- Resistance to thyroid hormone
- Thyroid hormone receptor defect
- Thyroid hormone resistance
comment
Impaired sensitivity to thyroid hormone may be accompanied by goiter and no clear symptoms and signs of thyrotoxicosis. The etiologies of this feature include defects in the thyroid hormone receptor, reduced cellular access of the biologically active thyroid hormone, T3 related to defects of thyroid hormone cell membrane transport, and a defect reducing the intracellular metabolism generating T3 from T4.
has alternative id
HP:0008262, HP:0008243, HP:0008215
has obo namespace
human_phenotype
id
HP:0002930