Terminology Service for NFDI4Health
Granulomatosis
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http://purl.obolibrary.org/obo/HP_0002955
A granulomatous inflammation leading to multiple granuloma formation, which is a specific type of inflammation. A granuloma is a focal compact collection of inflammatory cells, mononuclear cells predominating, usually as a result of the persistence of a non-degradable product and of active cell mediated hypersensitivity. [ http://www.ncbi.nlm.nih.gov/pubmed/10908370 http://www.ncbi.nlm.nih.gov/pubmed/937513 ]
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Label
Granulomatosis
comment
This finding can be demonstrated by tissue biopsy. A granuloma is a compact (organized) collection of mature mononuclear phagocytes (macrophages and/or epithelioid cells) which may or may not be accompanied by accessory features such as necrosis or the infiltration of other inflammatory leukocytes (Adams DO. The granulomatous inflammatory response. Am J Pathol 1976:84:163-192).
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human_phenotype
id
HP:0002955