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Ph-positive acute lymphoblastic leukemia

Go to external page http://purl.obolibrary.org/obo/HP_0004848

A subset of acute lymphoblastic leukemia that results from a reciprocal translocation between the ABL-1 oncogene and a breakpoint cluster region (BCR), resulting in a fusion gene, BCR-ABL, that encodes an oncogenic protein with constitutively active tyrosine kinase activity. [ http://www.ncbi.nlm.nih.gov/pubmed/21472706 ]

Term info

Label

Ph-positive acute lymphoblastic leukemia

Synonyms
  • Philadelphia-positive acute lymphoblastic leukemia
database cross reference
has obo namespace

human_phenotype

id

HP:0004848

Term relations