Terminology Service for NFDI4Health

Abnormal bone ossification

Go to external page http://purl.obolibrary.org/obo/HP_0011849


Any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. [ http://www.ncbi.nlm.nih.gov/pubmed/18157903 ]

Term info

Label

Abnormal bone ossification

database cross reference
layperson term
Abnormal bone maturation [ ORCID : 0000-0001-5208-3432 ]

comment

All bones are formed by the replacement by osteocytes of mesenchyme-derived connective tissue. Intramembranous ossification refers to the direct replacement of primitive mesenchyme with bone, and is responsible for bones such as the calvarium (e.g., frontals, parietals, interparietal) and the clavicula. In endochondral ossification, the mesenchyme differentiates into a cartilaginous intermediate, which serves as a template (anlange) that is subsequently removed and replaced by bone. Most bones are formed via endochondral ossification, including those at the base of the skull, the vertebral column, pectoral and pelvic regions and long bones of the extremities. A reduction in the amount of mineralized bone compared with that expected for a given developmental age. In clinicakl parlance, reduced ossification and delayed ossification are often used synonymously, but in principle a bone delayed ossification in a child can display normal ossification at a later developmental stage. The HPO will therefore treat poor, reduced, and decreased officiation as synonymous, and delayed ossification as a specific kind of reduced ossification.

created by

peter

creation date

2012-05-15T07:39:58Z

has obo namespace

human_phenotype

has related synonym

Abnormal bone maturation

id

HP:0011849

Term relations

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