Corneal guttata are droplet-like accumulations of non-banded collagen on the posterior surface of Descemet's membrane. The presence of focal thickenings of Descemet's membrane histologically named guttae. Cornea guttata can be easily diagnosed in vivo and ex vivo by means of specular microscopy as it gives dark areas where no endothelial cells are visible. [ http://www.ncbi.nlm.nih.gov/pubmed/11222329 http://www.ncbi.nlm.nih.gov/pubmed/10611102 ]