Terminology Service for NFDI4Health
Abnormal ciliary motility
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http://purl.obolibrary.org/obo/HP_0012262
Any anomaly of the normal motility of motile cilia. Evaluation of ciliary beat frequency and ciliary beat pattern requires high-speed videomicroscopy of freshly obtained ciliary biopsies that are maintained in culture media under controlled conditions. [ http://www.ncbi.nlm.nih.gov/pubmed/19606528 http://www.ncbi.nlm.nih.gov/pubmed/20301301 ]
Term info
Label
Abnormal ciliary motility
comment
Ciliated epithelial cells bear approximately 200 motile (9 + 2) cilia that move with both intracellular and intercellular synchrony. The pattern of beat in 9 + 2 motile cilia occurs in a waveform having a forward effective stroke followed by a return stroke. The direction of stroke is a function of the directional orientation of the central microtubules. In addition to moving in synchrony, individual cilia in normal cells are very plastic and move fluidly, sometimes deforming briefly upon encountering resistance and/or particles being transported over the mucosal surface. Cilia are embedded in a watery periciliary fluid of low viscosity, which facilitates the rapid beat cycle to move the more viscous overlying layer of mucus. Ciliary beat frequency ranges from approximately 8-20 Hz under normal conditions but may be accelerated by exposure to irritants such as tobacco smoke.
created by
peter
creation date
2013-04-07T10:10:35Z
has obo namespace
human_phenotype
id
HP:0012262