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Abnormal proportion of double-negative alpha-beta regulatory T cell

Go to external page http://purl.obolibrary.org/obo/HP_0031399

An abnormal proportion of CD4-negative, CD8-negative (double negative or DN) alpha-beta regulatory T cells (Tregs) as compared to total number of T cells. [ http://www.ncbi.nlm.nih.gov/pubmed/16285891 http://www.ncbi.nlm.nih.gov/pubmed/22294241 ]

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Label

Abnormal proportion of double-negative alpha-beta regulatory T cell

Synonyms
  • Abnormal CD4-negative, CD8-negative, alpha-beta regulatory T cell distribution
  • Abnormal DN Treg distribution
  • Abnormal Double negative Treg distribution
  • Abnormal double-negative alpha-beta regulatory T cell distribution
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T lymphocytes bearing the alpha-beta T cell receptor (TCR) but lacking CD4, CD8, and markers of natural killer (NK) cell differentiation, i.e., TCR(+)CD3(+)CD4(-)CD8(-), are known as double-negative (DN) T cells and are defined by their capability of inhibiting immune responses via directly killing effector T cells in an antigen specific fashion. Furthermore, DN Treg cells have been shown to develop regulatory activity after encountering specific antigens, partially mediated by the acquisition of MHC-peptide complexes from antigen presenting cells (APCs).

created by

peter

date

2017-09-03T12:57:22Z

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