Terminology Service for NFDI4Health
cortical subplate
Go to external page
http://purl.obolibrary.org/obo/UBERON_0004035
The transient outer neural tube region that contains the first generated post-mitotic neurons that receive synaptic input from thalamic axons and in turn project axons to the developing cortical plate [ http://en.wikipedia.org/wiki/Subplate https://github.com/obophenotype/mouse-anatomy-ontology/issues/1 ]
Term info
Label
cortical subplate
Synonyms
- cerebral cortex subplate
- subplate
- subplate zone
Subsets
pheno_slim
development notes
The transient fetal subplate zone, together with the marginal zone and the cortical plate, represents the developmental anlage of the mammalian cerebral cortex. It serves as a waiting compartment for growing cortical afferents; its cells are involved in the establishment of pioneering cortical efferent projections and transient fetal circuitry, and apparently have a number of other developmental roles. The subplate zone is a phylogenetically recent structure and it is most developed in the human brain. Subplate neurons are among the first generated neurons in the mammalian cerebral cortex [1]. These neurons disappear during postnatal development and are important in establishing the correct wiring [2][3] and functional maturation [4] of the cerebral cortex. Subplate neurons appear to be selectively sensitive to injury (such as hypoxia) which in humans are associated with motor and cognitive defects
has obo namespace
uberon
id
UBERON:0004035
Term relations
Equivalent to:
- layer of developing cerebral cortex and adjacent_to some cortical intermediate zone and adjacent_to some cortical plate
Subclass of:
- layer of developing cerebral cortex
- adjacent_to some cortical plate
- develops from some cortical preplate
- adjacent_to some cortical intermediate zone
Related from: