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Amyotrophic Lateral Sclerosis

http://purl.bioontology.org/ontology/MESH/D000690

A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)

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Instance info

Synonyms

Amyotrophic Lateral Sclerosis, Guam Form, ALS (Amyotrophic Lateral Sclerosis), Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1, Lateralsklerose, amyotrophische (DE), ALS (DE), Guam Disease, Gehrig's Disease, Dementia With Amyotrophic Lateral Sclerosis, Lou-Gehrigs Disease, Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1, Gehrigs Disease, Disease, Guam, Myatrophische Lateralsklerose (DE), Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam, Sclerosis, Amyotrophic Lateral, Guam Form of Amyotrophic Lateral Sclerosis, Disease, Lou-Gehrigs, Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam, Charcot-Syndrom II (DE), Gehrig-Krankheit (DE), Charcot Disease, Motor Neuron Disease, Amyotrophic Lateral Sclerosis, Amyotrophische Lateralsklerose (DE), Lou Gehrig's Disease, Lateralsklerose, myatrophische (DE), Motoreuronerkrankung, amyotrophe Lateralsklerose (DE), Loe-Gehrig-Krankheit (DE), Amyotrophic Lateral Sclerosis With Dementia, Lou Gehrig Disease, Gehrig Disease

AQL

BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI

19660101

MDA

19990101

MMR

20130708

C10.228.854.139,C10.574.950.050,C10.574.562.250,C18.452.845.800.050,C10.668.467.250

http://purl.bioontology.org/ontology/MESH/Q000097,http://purl.bioontology.org/ontology/MESH/Q000175,http://purl.bioontology.org/ontology/MESH/Q000196,http://purl.bioontology.org/ontology/MESH/Q000151,http://purl.bioontology.org/ontology/MESH/Q000150,http://purl.bioontology.org/ontology/MESH/Q000191,http://purl.bioontology.org/ontology/MESH/Q000139,http://purl.bioontology.org/ontology/MESH/Q000534,http://purl.bioontology.org/ontology/MESH/Q000378,http://purl.bioontology.org/ontology/MESH/Q000532,http://purl.bioontology.org/ontology/MESH/Q000235,http://purl.bioontology.org/ontology/MESH/Q000652,http://purl.bioontology.org/ontology/MESH/Q000178,http://purl.bioontology.org/ontology/MESH/Q000453,http://purl.bioontology.org/ontology/MESH/Q000134,http://purl.bioontology.org/ontology/MESH/Q000276,http://purl.bioontology.org/ontology/MESH/Q000473,http://purl.bioontology.org/ontology/MESH/Q000000981,http://purl.bioontology.org/ontology/MESH/Q000451,http://purl.bioontology.org/ontology/MESH/Q000517,http://purl.bioontology.org/ontology/MESH/Q000382,http://purl.bioontology.org/ontology/MESH/Q000601,http://purl.bioontology.org/ontology/MESH/Q000821,http://purl.bioontology.org/ontology/MESH/Q000469,http://purl.bioontology.org/ontology/MESH/Q000523,http://purl.bioontology.org/ontology/MESH/Q000401,http://purl.bioontology.org/ontology/MESH/Q000201,http://purl.bioontology.org/ontology/MESH/Q000662,http://purl.bioontology.org/ontology/MESH/Q000266,http://purl.bioontology.org/ontology/MESH/Q000145,http://purl.bioontology.org/ontology/MESH/Q000188,http://purl.bioontology.org/ontology/MESH/Q000628,http://purl.bioontology.org/ontology/MESH/Q000209,http://purl.bioontology.org/ontology/MESH/Q000208,http://purl.bioontology.org/ontology/MESH/Q000503

SIB

http://purl.bioontology.org/ontology/MESH/D057174,http://purl.bioontology.org/ontology/MESH/D009187,http://purl.bioontology.org/ontology/MESH/D010244,http://purl.bioontology.org/ontology/MESH/D013132,http://purl.bioontology.org/ontology/MESH/D013120,http://purl.bioontology.org/ontology/MESH/D063205,http://purl.bioontology.org/ontology/MESH/D009134,http://purl.bioontology.org/ontology/MESH/D016750,http://purl.bioontology.org/ontology/MESH/D013595,http://purl.bioontology.org/ontology/MESH/D013606,http://purl.bioontology.org/ontology/MESH/D013117,http://purl.bioontology.org/ontology/MESH/D052879,http://purl.bioontology.org/ontology/MESH/D013119,http://purl.bioontology.org/ontology/MESH/D020802,http://purl.bioontology.org/ontology/MESH/D020758

TERMUI

T002092,T782950,T002091,T002090,T845605,T814256,T366063,T366064,T753625,T366069,T366065,T366066,T366067,T366068,T840894

GHR (2014),NLM (1990),ORD (2010),NLM (1966),NLM (2000),NLM (2010),NLM (2014),NLM (2013),BIOETHICS (1998),NLM (2012)

cui

C0393554,C0543859,C0002736

hasSTY

http://purl.bioontology.org/ontology/STY/T047

mapped from

http://purl.bioontology.org/ontology/MESH/C563708,http://purl.bioontology.org/ontology/MESH/C565956,http://purl.bioontology.org/ontology/MESH/C565957,http://purl.bioontology.org/ontology/MESH/C567429,http://purl.bioontology.org/ontology/MESH/C531617,http://purl.bioontology.org/ontology/MESH/C565955,http://purl.bioontology.org/ontology/MESH/C563895,http://purl.bioontology.org/ontology/MESH/C564688,http://purl.bioontology.org/ontology/MESH/C564300,http://purl.bioontology.org/ontology/MESH/C567699,http://purl.bioontology.org/ontology/MESH/C566576,http://purl.bioontology.org/ontology/MESH/C567499,http://purl.bioontology.org/ontology/MESH/C566288,http://purl.bioontology.org/ontology/MESH/C567244,http://purl.bioontology.org/ontology/MESH/C566550,http://purl.bioontology.org/ontology/MESH/C538251,http://purl.bioontology.org/ontology/MESH/C566290

tui

T047

Instance relations

Types

Class