A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)
Instance info
Tonic-Clonic Convulsion Disorder, Convulsion Syndromes, Tonic-Clonic, Convulsion Disorder, Tonic-Clonic, Tonic-Clonic Epilepsy, Major Epilepsies, Syndromes, Tonic-Clonic Convulsion, Epilepsy, Symptomatic Tonic-Clonic, Tonic-Clonic Epilepsies, Cryptogenic, Epilepsie, Grand mal (DE), Seizure Syndrome, Tonic-Clonic, Seizure Syndromes, Tonic-Clonic, Grand-mal-Epilepsie (DE), Epilepsy, Tonic-Clonic, Symptomatic, Epilepsy, Grand Mal, Generalisierte motorische epileptische Anfälle (DE), Epilepsy, Tonic-Clonic, Familial, Disorder, Tonic-Clonic Seizure, Convulsion, Tonic Clonic, Convulsions, Grand Mal, Disorder, Tonic-Clonic Convulsion, Tonic Clonic Seizure Disorder, Seizure Disorder, Major Motor, Convulsions, Tonic Clonic, Grand Mal Epilepsy, Familial Tonic Clonic Epilepsy, Tonic-Clonic Epilepsy, Cryptogenic, Cryptogenic Tonic Clonic Epilepsy, Tonic-Clonic Epilepsy, Symptomatic, Major Epilepsy, Tonic-Clonic Seizure Syndrome, Epilepsie, tonisch-klonische (DE), Epilepsia major (DE), Tonic-Clonic Epilepsies, Familial, Convulsion, Grand Mal, Symptomatic Tonic-Clonic Epilepsy, Tonic Clonic Convulsion Syndrome, Seizure Disorder, Tonic Clonic, Tonic-Clonic Convulsion Disorders, Major Motor Seizure Disorder, Convulsion Syndrome, Tonic-Clonic, Epilepsy, Tonic-Clonic, Cryptogenic, Seizure Disorders, Tonic-Clonic, Convulsion Disorders, Tonic-Clonic, Grand Mal Seizure Disorder, Tonic Clonic Seizure Syndrome, Disorders, Tonic-Clonic Seizure, Seizure Disorder, Tonic-Clonic, Epilepsies, Familial Tonic-Clonic, Epilepsy, Major, Epilepsy, Familial Tonic-Clonic, Syndrome, Tonic-Clonic Seizure, Tonic-Clonic Convulsion Syndrome, Epilepsies, Tonic-Clonic, Epileptische Anfälle, tonisch-klonische (DE), Tonic-Clonic Seizure Disorders, Tonic-Clonic Epilepsy, Familial, Syndrome, Tonic-Clonic Convulsion, Cryptogenic Tonic-Clonic Epilepsies, Familial Tonic-Clonic Epilepsy, Epilepsy, Cryptogenic Tonic-Clonic, Epilepsy, Tonic Clonic, Tonic Clonic Convulsions, Tonic Clonic Convulsion Disorder, Disorders, Tonic-Clonic Convulsion, Grand Mal Convulsion, Syndromes, Tonic-Clonic Seizure, Seizure Disorder, Grand Mal, Epilepsies, Symptomatic Tonic-Clonic, Tonic-Clonic Seizure Disorder, Symptomatic Tonic-Clonic Epilepsies, Tonic Clonic Convulsion, Familial Tonic-Clonic Epilepsies, Grand Mal Convulsions, Epilepsies, Cryptogenic Tonic-Clonic, Tonic-Clonic Epilepsies, Tonic-Clonic Convulsion Syndromes, Symptomatic Tonic Clonic Epilepsy, Tonic-Clonic Seizure Syndromes, Tonic-Clonic Epilepsies, Symptomatic, Cryptogenic Tonic-Clonic Epilepsy
do not confuse with EPILEPSY, TONIC see EPILEPSY, GENERALIZED
BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI
1
19920101
1992(1963)
19990101
20050730
C10.228.140.490.375.290
1992; see EPILEPSY, GRAND MAL 1963-1991
http://purl.bioontology.org/ontology/MESH/Q000097,http://purl.bioontology.org/ontology/MESH/Q000175,http://purl.bioontology.org/ontology/MESH/Q000196,http://purl.bioontology.org/ontology/MESH/Q000151,http://purl.bioontology.org/ontology/MESH/Q000150,http://purl.bioontology.org/ontology/MESH/Q000191,http://purl.bioontology.org/ontology/MESH/Q000139,http://purl.bioontology.org/ontology/MESH/Q000534,http://purl.bioontology.org/ontology/MESH/Q000378,http://purl.bioontology.org/ontology/MESH/Q000532,http://purl.bioontology.org/ontology/MESH/Q000235,http://purl.bioontology.org/ontology/MESH/Q000652,http://purl.bioontology.org/ontology/MESH/Q000178,http://purl.bioontology.org/ontology/MESH/Q000453,http://purl.bioontology.org/ontology/MESH/Q000134,http://purl.bioontology.org/ontology/MESH/Q000276,http://purl.bioontology.org/ontology/MESH/Q000000981,http://purl.bioontology.org/ontology/MESH/Q000473,http://purl.bioontology.org/ontology/MESH/Q000451,http://purl.bioontology.org/ontology/MESH/Q000517,http://purl.bioontology.org/ontology/MESH/Q000382,http://purl.bioontology.org/ontology/MESH/Q000469,http://purl.bioontology.org/ontology/MESH/Q000601,http://purl.bioontology.org/ontology/MESH/Q000821,http://purl.bioontology.org/ontology/MESH/Q000523,http://purl.bioontology.org/ontology/MESH/Q000401,http://purl.bioontology.org/ontology/MESH/Q000201,http://purl.bioontology.org/ontology/MESH/Q000145,http://purl.bioontology.org/ontology/MESH/Q000266,http://purl.bioontology.org/ontology/MESH/Q000662,http://purl.bioontology.org/ontology/MESH/Q000188,http://purl.bioontology.org/ontology/MESH/Q000628,http://purl.bioontology.org/ontology/MESH/Q000209,http://purl.bioontology.org/ontology/MESH/Q000208,http://purl.bioontology.org/ontology/MESH/Q000503
http://purl.bioontology.org/ontology/MESH/D064128,http://purl.bioontology.org/ontology/MESH/D004832,http://purl.bioontology.org/ontology/MESH/D013036,http://purl.bioontology.org/ontology/MESH/D004831
T368080,T014725,T014724,T368075,T368063,T368074,T368077,T368076,T368071,T368060,T368073,T368062,T368072,T368061,T368079,T368057,T368078,T368056,T368059,T368058
NLM (1992),NLM (1966),NLM (2000)
C0751118,C0751119,C0751117,C0014549
http://purl.bioontology.org/ontology/STY/T047
http://purl.bioontology.org/ontology/MESH/C564607
T047