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Threonine Aspartase 1

Go to external page http://purl.obolibrary.org/obo/NCIT_C102896

Threonine aspartase 1 (420 aa, ~44 kDa) is encoded by the human TASP1 gene. This protein plays a role in the proteolysis of histone-lysine N-methyltransferase MLL protein. [ ]

Term info

Label

Threonine Aspartase 1

Synonyms
  • EC 3.4.25.-
  • Taspase 1
  • Taspase-1
  • Threonine Aspartase 1
DesignNote

Threonine aspartase 1 cleaves histone-lysine N-methyltransferase MLL which both increases the stability and enhances the nuclear localization for the MLL protein. (OMIM), Threonine aspartase 1 undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble non-covalently into the active alpha2-beta2 heterotetramer. (EntrezGene and UniProt)

OMIM Number

608270

Preferred Name

Threonine Aspartase 1

Semantic Type

Amino Acid, Peptide, or Protein, Enzyme

Swiss Prot

Q9H6P5

UMLS CUI

C3541322

code

C102896