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Fenretinide

Go to external page http://purl.obolibrary.org/obo/NCIT_C1098

An orally-active synthetic phenylretinamide analogue of retinol (vitamin A) with potential antineoplastic and chemopreventive activities. Fenretinide binds to and activates retinoic acid receptors (RARs), thereby inducing cell differentiation and apoptosis in some tumor cell types. This agent also inhibits tumor growth by modulating angiogenesis-associated growth factors and their receptors and exhibits retinoid receptor-independent apoptotic properties. (NCI04) [ ]

Term info

Label

Fenretinide

Synonyms
  • 4-(all-trans-retino-yl)aminophenol
  • 4-HPR
  • 4-Hydroxyphenylretinamide
  • All-trans-4'-Hydroxyretinanilide
  • FENRETINIDE
  • Fenretinide
  • Fenretinimide
  • HPR-4
  • McN-R-1967
  • N-(4-hydroxyphenyl)retinamide
  • all-trans-4'-hydroxyretinanilide
  • all-trans-N-(4-Hydroxyphenyl)retinamide
  • all-trans-N-4'-hydroxyretinanilide
  • fenretinide
Subsets

NCIT_C116978, NCIT_C128784, NCIT_C63923, NCIT_C157711, NCIT_C116977, NCIT_C157712

ALT DEFINITION

A substance being studied in the treatment and prevention of some types of cancer. Fenretinide may cause ceramide (a wax-like substance) to build up in tumor cells and kill them. It is a type of retinoid, which are substances related to vitamin A.

CAS Registry

65646-68-6

CHEBI ID

CHEBI:42588

Chemical Formula

C26H33NO2

Display Name

Fenretinide

FDA UNII Code

187EJ7QEXL

Has Target

http://purl.obolibrary.org/obo/NCIT_C17532

Legacy Concept Name

Fenretinide

NSC Code

374551

Preferred Name

Fenretinide

Semantic Type

Pharmacologic Substance, Organic Chemical

UMLS CUI

C0060197

code

C1098