Terminology Service for NFDI4Health

Liposomal Eribulin Mesylate

Go to external page http://purl.obolibrary.org/obo/NCIT_C111899


A liposome-encapsulated formulation of the mesylate salt form of eribulin, a synthetic, macrocyclic ketone analogue of halichondrin B, a substance derived from the marine sponge genus Halichondria, with potential antineoplastic activity. Eribulin binds to the vinca domain of tubulin and inhibits both the polymerization of tubulin and the assembly of microtubules. This results in the inhibition of mitotic spindle assembly, the induction of cell cycle arrest at G2/M phase, as well as tumor cell apoptosis. Compared to the administration of eribulin alone, liposomal delivery of eribulin allows for a longer half-life, which allows increased drug concentration in target tissues while decreasing systemic toxicity. [ ]

Term info

Label

Liposomal Eribulin Mesylate

Synonyms
  • E7389 Liposomal Formulation
  • E7389-LF
  • Liposomal Eribulin Mesylate
Subsets

NCIT_C128784, NCIT_C157711, NCIT_C157712

Has Target

http://purl.obolibrary.org/obo/NCIT_C17219

NCI META CUI

CL454231

Preferred Name

Liposomal Eribulin Mesylate

Semantic Type

Pharmacologic Substance

code

C111899