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Hypoxia Inducible Factor Family

Go to external page http://purl.obolibrary.org/obo/NCIT_C113839

A family of basic helix-loop-helix heterodimeric transcription factors that activate gene expression when oxygen levels decrease in the cellular environment. Each HIF complex is comprised of an alpha subunit and beta subunit, which are encoded by separate genes. [ ]

Term info

Label

Hypoxia Inducible Factor Family

Synonyms
  • HIF
  • HIF Factor
  • HIF Family
  • Hypoxia Inducible Factor
  • Hypoxia Inducible Factor Family
  • Hypoxia-Inducible Factor
  • Hypoxia-Inducible Factor Family
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

DesignNote

During normoxic conditions, the alpha subunits of HIF are hydroxylated at conserved proline residues by prolyl-hydroxylase enzymes. This modification promotes alpha subunit ubiquitination, which leads to proteasomal degradation. In hypoxic conditions, prolyl-hydroxylase activity is inhibited; therefore, the half-life of the alpha subunits are prolonged and they are able to dimerize with the appropriate beta subunit to regulate the expression of hypoxia-responsive genes.

Display Name

Hypoxia Inducible Factor Family

Preferred Name

Hypoxia Inducible Factor Family

Semantic Type

Amino Acid, Peptide, or Protein

UMLS CUI

C3811709

code

C113839