Terminology Service for NFDI4Health

EGFR-GRB2 Complex

Go to external page http://purl.obolibrary.org/obo/NCIT_C116967


A protein complex comprised of two epidermal growth factor receptor (EGFR) family proteins, and one or two growth factor receptor-bound protein 2 (GRB2) adaptor proteins. These complexes form after epidermal growth factor (EGF) family ligands bind to EGFR proteins. Ligand binding triggers receptor dimerization and cross-receptor tyrosine phosphorylation, which allows the SH2 domains of each growth factor receptor-bound protein 2 to form a non-covalent bond with the phosphorylated EGFR proteins. [ ]

Term info

Label

EGFR-GRB2 Complex

Synonyms
  • EGFR-GRB2 Complex
  • EGFR-GRB2 Signaling Complex
  • EGFR:GRB2 Complex
  • EGFR:GRB2 Signaling Complex
  • GRB2-EGFR Complex
  • GRB2:EGFR Complex
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

Display Name

EGFR-GRB2 Complex

Preferred Name

EGFR-GRB2 Complex

Semantic Type

Amino Acid, Peptide, or Protein

UMLS CUI

C2611190

code

C116967