EGFR-GRB2 Complex
A protein complex comprised of two epidermal growth factor receptor (EGFR) family proteins, and one or two growth factor receptor-bound protein 2 (GRB2) adaptor proteins. These complexes form after epidermal growth factor (EGF) family ligands bind to EGFR proteins. Ligand binding triggers receptor dimerization and cross-receptor tyrosine phosphorylation, which allows the SH2 domains of each growth factor receptor-bound protein 2 to form a non-covalent bond with the phosphorylated EGFR proteins. [ ]
Term info
EGFR-GRB2 Complex
- EGFR-GRB2 Complex
- EGFR-GRB2 Signaling Complex
- EGFR:GRB2 Complex
- EGFR:GRB2 Signaling Complex
- GRB2-EGFR Complex
- GRB2:EGFR Complex
NCIT_C116977, NCIT_C142800, NCIT_C142799
CTRP
EGFR-GRB2 Complex
EGFR-GRB2 Complex
Amino Acid, Peptide, or Protein
C2611190
C116967