Terminology Service for NFDI4Health
Proheparin-Binding EGF-Like Growth Factor
Go to external page
http://purl.obolibrary.org/obo/NCIT_C118380
Proheparin-binding EGF-like growth factor (208 aa, ~23 kDa) is encoded by the human HBEGF gene. This protein plays a role in both heart valve formation and mitogenesis for fibroblasts and smooth muscle cells. [ ]
Term info
Label
Proheparin-Binding EGF-Like Growth Factor
Synonyms
- Pro-HB-EGF
- Proheparin-Binding EGF-Like Growth Factor
DesignNote
The active form of the growth factor, called heparin-binding EGF-like growth factor, is produced by two proteolytic cleavage events that remove 62 N-terminal amino acids and 60 amino acids from the C-terminus of proheparin-binding EGF-like growth factor. The precursor is a type I membrane protein and the mature form is a secreted protein. (UniProt)
OMIM Number
126150
Preferred Name
Proheparin-Binding EGF-Like Growth Factor
Semantic Type
Amino Acid, Peptide, or Protein
Swiss Prot
Q99075
UMLS CUI
C3888283
code
C118380
Term relations
Subclass of:
- HBEGF Gene Product
- Gene_Product_Has_Chemical_Classification some Transmembrane Protein
- Gene_Product_Expressed_In_Tissue some Fibroblast
- Gene_Product_Has_Biochemical_Function some Heparin Binding Growth Factor
- Gene_Product_Has_Structural_Domain_Or_Motif some EGF-Like Domain
- Gene_Product_Plays_Role_In_Biological_Process some Receptor Signaling
- Gene_Product_Has_Associated_Anatomy some Plasma Membrane
- Gene_Product_Has_Organism_Source some Human
- Gene_Product_Expressed_In_Tissue some Smooth Muscle Cell
- Gene_Product_Encoded_By_Gene some HBEGF Gene
- Gene_Product_Plays_Role_In_Biological_Process some Heparin Binding
- Gene_Product_Has_Structural_Domain_Or_Motif some Transmembrane Domain