Terminology Service for NFDI4Health
Pro-Neuregulin-1, Membrane-Bound Isoform
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http://purl.obolibrary.org/obo/NCIT_C118414
Pro-neuregulin-1, membrane-bound isoform (640 aa, ~70 kDa) is encoded by the human NRG1 gene. This protein plays a role in tyrosine kinase receptor-mediated signal transduction. [ ]
Term info
Label
Pro-Neuregulin-1, Membrane-Bound Isoform
Synonyms
- Pro-NRG1
- Pro-Neuregulin-1
- Pro-Neuregulin-1, Membrane-Bound Isoform
Subsets
NCIT_C116977, NCIT_C142800, NCIT_C142799
Contributing Source
CTRP
DesignNote
The active form of the growth factor, neuregulin-1, is produced by two proteolytic cleavage events that remove the 19 N-terminal amino acid signal sequence and 399 amino acids from the C-terminus of pro-neuregulin-1, membrane-bound isoform. The precursor is a type I membrane protein and the mature form is a secreted protein. (UniProt)
Display Name
Pro-Neuregulin-1, Membrane-Bound Isoform
OMIM Number
142445
Preferred Name
Pro-Neuregulin-1, Membrane-Bound Isoform
Semantic Type
Amino Acid, Peptide, or Protein
Swiss Prot
Q02297
UMLS CUI
C3888287
code
C118414
Term relations
Subclass of:
- NRG1 Gene Product
- Gene_Product_Has_Structural_Domain_Or_Motif some EGF-Like Domain
- Gene_Product_Plays_Role_In_Biological_Process some Intercellular Communication Process
- Gene_Product_Encoded_By_Gene some NRG1 Gene
- Gene_Product_Has_Biochemical_Function some Transmembrane Protein
- Gene_Product_Has_Associated_Anatomy some Plasma Membrane
- Gene_Product_Plays_Role_In_Biological_Process some Cell Differentiation Process
- Gene_Product_Has_Structural_Domain_Or_Motif some Transmembrane Domain